Relationship between liver iron concentration determined by R2-MRI, serum ferritin, and liver enzymes in patients with thalassemia intermedia
Blood Research
;
: 314-319, 2018.
Article
in English
| WPRIM
| ID: wpr-718478
ABSTRACT
BACKGROUND:
Iron overload is a risk factor affecting all patients with thalassemia intermedia (TI). We aimed to determine whether there is a relationship of serum ferritin (SF) and alanine aminotransferase (ALT) with liver iron concentration (LIC) determined by R2 magnetic resonance imaging (R2-MRI), to estimate the most relevant degree of iron overload and best time to chelate in patients with TI.METHODS:
In this cross-sectional study, 119 patients with TI (mean age years) were randomly selected and compared with 120 patients who had a diagnosis of thalassemia major (TM). Correlations of LIC, as determined by R2-MRI, with SF and ALT levels, were assessed in all participants. A P-value 5 mg Fe/g dry weight (P < 0.0001). A significant relationship was also found for patients with TI who had elevated ALT level (63.5 U/L), of 3.15 times the upper normal laboratory limit, using a cut-off for LIC ≥5 mg Fe/g dry weight.CONCLUSION:
We determined the cut-off values for ALT and SF indicating the best time to start iron chelation therapy in patients with TI, and found significant correlations among iron overload, SF, and ALT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Splenectomy
/
Thalassemia
/
Magnetic Resonance Imaging
/
Chelation Therapy
/
Cross-Sectional Studies
/
Risk Factors
/
Puberty
/
Beta-Thalassemia
/
Iron Overload
/
Diagnosis
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adolescent
/
Humans
Language:
English
Journal:
Blood Research
Year:
2018
Type:
Article
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