The Brain Donation Program in South Korea
Yonsei Medical Journal
;
: 1197-1204, 2018.
Article
in English
| WPRIM
| ID: wpr-718491
ABSTRACT
PURPOSE:
Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerative diseases. We are aiming to facilitate analyses of clinic-pathological and image-pathological correlations of neurodegenerative disease and to broaden understanding thereof. MATERIALS ANDMETHODS:
We recruited participants through two routes from memory clinics and the community. As a baseline evaluation, clinical interviews, a neurological examination, laboratory tests, neuropsychological tests, and MRI were undertaken. Some patients also underwent amyloid PET.RESULTS:
We recruited 105 participants, 70 from clinics and 35 from the community. Among them, 11 died and were autopsied. The clinical diagnoses of the autopsied patients included four with Alzheimer's disease (AD), two with subcortical vascular dementia, two with non-fluent variant primary progressive aphasia, one with leukoencephalopathy, one with frontotemporal dementia (FTD), and one with Creutzfeldt-Jakob disease (CJD). Five patients underwent amyloid PET two with AD, one with mixed dementia, one with FTD, and one with CJD.CONCLUSION:
The clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asia
/
Brain
/
Magnetic Resonance Imaging
/
Dementia, Vascular
/
Cohort Studies
/
Creutzfeldt-Jakob Syndrome
/
Cognition Disorders
/
Aphasia, Primary Progressive
/
Neurodegenerative Diseases
/
Dementia
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2018
Type:
Article
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