Anesthetic and Perioperative Management of Patient with Paroxysmal Nocturnal Hemoglobinuria / 계명의대학술지
Keimyung Medical Journal
;
: 92-96, 2018.
Article
in English
| WPRIM
| ID: wpr-718506
ABSTRACT
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder. Surgery, anesthesia, infection, trauma, and pregnancy can exacerbate hemolysis and thrombotic risk by increasing complement activity. However, perioperative treatment of eculizumab can reduce risk of hemolytic event by surgical stress. Here, we present the perioperative clinical course and adequate anesthetic management of PNH complicated by spine surgery under general anesthesia. We also describe a possible role of eculizumab for PNH patients with anticipated high risks.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spine
/
Thrombosis
/
Complement System Proteins
/
Hematopoietic Stem Cells
/
Hemoglobinuria
/
Hemoglobinuria, Paroxysmal
/
Hemolysis
/
Anesthesia
/
Anesthesia, General
Limits:
Humans
/
Pregnancy
Language:
English
Journal:
Keimyung Medical Journal
Year:
2018
Type:
Article
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