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Anesthetic and Perioperative Management of Patient with Paroxysmal Nocturnal Hemoglobinuria / 계명의대학술지
Keimyung Medical Journal ; : 92-96, 2018.
Article in English | WPRIM | ID: wpr-718506
ABSTRACT
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder. Surgery, anesthesia, infection, trauma, and pregnancy can exacerbate hemolysis and thrombotic risk by increasing complement activity. However, perioperative treatment of eculizumab can reduce risk of hemolytic event by surgical stress. Here, we present the perioperative clinical course and adequate anesthetic management of PNH complicated by spine surgery under general anesthesia. We also describe a possible role of eculizumab for PNH patients with anticipated high risks.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spine / Thrombosis / Complement System Proteins / Hematopoietic Stem Cells / Hemoglobinuria / Hemoglobinuria, Paroxysmal / Hemolysis / Anesthesia / Anesthesia, General Limits: Humans / Pregnancy Language: English Journal: Keimyung Medical Journal Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spine / Thrombosis / Complement System Proteins / Hematopoietic Stem Cells / Hemoglobinuria / Hemoglobinuria, Paroxysmal / Hemolysis / Anesthesia / Anesthesia, General Limits: Humans / Pregnancy Language: English Journal: Keimyung Medical Journal Year: 2018 Type: Article