Heat-Killed Saccharomyces cerevisiae, A Dectin-1 Agonist, Selectively Induces IgG4 Production by Human B Cells
Immune Network
;
: e46-2018.
Article
in English
| WPRIM
| ID: wpr-718579
ABSTRACT
Dectin-1 is a major receptor that recognizes fungal cell wall β-glucan. We previously reported that heat-killed Saccharomyces cerevisiae (HKSC), a Dectin-1 agonist, selectively induces IgG1 class switching in mouse B cells. Dectin-1 is also expressed on human B cells; however, Dectin-1 function in human B cells remains unknown. This study aimed to investigate the direct effect of in vitro stimulation using HKSC on Ig class switching in human B cells. HKSC selectively induced the expression of germline γ4 transcripts (GLTγ4) by human B cell line 2E2, and HKSC significantly augmented GLTγ4 promoter activity. Moreover, HKSC selectively enhanced GLTγ4 expression and IgG4 production by anti-CD40-activated human tonsillar resting B cells. Thus, these results suggest that Dectin-1 maybe involved in selective IgG4 class switching by human B cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Saccharomyces
/
Saccharomyces cerevisiae
/
In Vitro Techniques
/
Immunoglobulin G
/
B-Lymphocytes
/
Cell Line
/
Cell Wall
/
Immunoglobulin Class Switching
Limits:
Animals
/
Humans
Language:
English
Journal:
Immune Network
Year:
2018
Type:
Article
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