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Chemical Constituents of Essential Oils Possessing Anti-Influenza A/WS/33 Virus Activity
Osong Public Health and Research Perspectives ; (6): 348-353, 2018.
Article in English | WPRIM | ID: wpr-718593
ABSTRACT

OBJECTIVES:

This study was conducted to determine whether essential oils had anti-influenza A/WS/33 virus activity and whether there were specific compounds associated with this activity.

METHODS:

There were 63 essential oils evaluated for anti-influenza (A/WS/33 virus) activity using a cytopathic effect reduction method. The chemical composition of the anti-influenza essential oils was phytochemically analyzed by gas chromatography-mass spectrometry.

RESULTS:

The antiviral assays demonstrated that 11 of the 62 essential oils (100 μg/mL) possessed anti-influenza activity, reducing visible cytopathic effects of influenza A/WS/33 virus activity by > 30%. Furthermore, marjoram, clary sage and anise oils exhibited anti-influenza A/WS/33 virus activity of > 52.8%. However, oseltamivir (the anti-influenza A and B drug), showed cytotoxicity at the same concentration (100 μg/mL) as the essential oils. The chemical composition detected by GC–MS analysis, differed amongst the 3 most potent anti-viral essential oils (marjoram, clary sage and anise oils) except for linalool, which was detected in all 3 essential oils.

CONCLUSION:

This study demonstrated anti-influenza activity in 11 essential oils tested, with marjoram, clary sage and anise essential oils being the most effective at reducing visible cytopathic effects of the A/WS/33 virus. All 3 oils contained linalool, suggesting that this may have anti-influenza activity. Further investigation is needed to characterize the antiviral activity of linalool against influenza A/WS/33 virus.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Oils / Oils, Volatile / Pimpinella / Origanum / Influenza, Human / Oseltamivir / Gas Chromatography-Mass Spectrometry / Methods Language: English Journal: Osong Public Health and Research Perspectives Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oils / Oils, Volatile / Pimpinella / Origanum / Influenza, Human / Oseltamivir / Gas Chromatography-Mass Spectrometry / Methods Language: English Journal: Osong Public Health and Research Perspectives Year: 2018 Type: Article