Acute kidney injury in childhood-onset nephrotic syndrome: Incidence and risk factors in hospitalized patients
Kidney Research and Clinical Practice
;
: 347-355, 2018.
Article
in English
| WPRIM
| ID: wpr-718619
ABSTRACT
BACKGROUND:
Nephrotic syndrome (NS) is the most common glomerulopathy in children. Acute kidney injury (AKI) is a common complication of NS, caused by severe intravascular volume depletion, acute tubular necrosis, interstitial nephritis, or progression of NS. However, the incidence and risk factors of childhood-onset NS in Korea are unclear. Therefore, we studied the incidence, causes, and risk factors of AKI in hospitalized Korean patients with childhood-onset NS.METHODS:
We conducted a retrospective review of patients with childhood-onset NS who were admitted to our center from January 2015 to July 2017. Patients with decreased renal function or hereditary/secondary NS, as well as those admitted for management of other conditions unrelated to NS, were excluded.RESULTS:
During the study period, 65 patients with idiopathic, childhood-onset NS were hospitalized 90 times for management of NS or its complications. Of these 90 cases, 29 met the Kidney Disease Improving Global Outcomes criteria for AKI (32.2%). They developed AKI in association with infection (n = 12), NS aggravation (n = 11), dehydration (n = 3), and intravenous methylprednisolone administration (n = 3). Age ≥ 9 years at admission and combined use of cyclosporine and renin-angiotensin system inhibitors were risk factors for AKI.CONCLUSION:
AKI occurred in one-third of the total hospitalizations related to childhood-onset NS, owing to infection, aggravation of NS, dehydration, and possibly high-dose methylprednisolone treatment. Age at admission and use of nephrotoxic agents were associated with AKI. As the AKI incidence is high, AKI should be considered during management of high-risk patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Renin-Angiotensin System
/
Methylprednisolone
/
Incidence
/
Retrospective Studies
/
Risk Factors
/
Cyclosporine
/
Dehydration
/
Acute Kidney Injury
/
Hospitalization
/
Kidney Diseases
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2018
Type:
Article
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