Association between the simultaneous decrease in the levels of soluble vascular cell adhesion molecule-1 and S100 protein and good neurological outcomes in cardiac arrest survivors
Clinical and Experimental Emergency Medicine
;
(4): 211-218, 2018.
Article
in English
| WPRIM
| ID: wpr-718719
ABSTRACT
OBJECTIVE:
This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and S100 proteins within the first 24 hours after the return of spontaneous circulation were associated with good neurological outcomes in cardiac arrest survivors.METHODS:
This retrospective observational study was based on prospectively collected data from a single emergency intensive care unit (ICU). Twenty-nine out-of-hospital cardiac arrest survivors who were admitted to the ICU for post-resuscitation care were enrolled. Blood samples were collected at 0 and 24 hours after ICU admission. According to the 6-month cerebral performance category (CPC) scale, the patients were divided into good (CPC 1 and 2, n=12) and poor (CPC 3 to 5, n=17) outcome groups.RESULTS:
No difference was observed between the two groups in terms of the serum levels of ICAM-1, VCAM-1, E-selectin, and S100 at 0 and 24 hours. A simultaneous decrease in the serum levels of VCAM-1 and S100 as well as E-selectin and S100 was associated with good neurological outcomes. When other variables were adjusted, a simultaneous decrease in the serum levels of VCAM-1 and S100 was independently associated with good neurological outcomes (odds ratio, 9.285; 95% confidence interval, 1.073 to 80.318; P=0.043).CONCLUSION:
A simultaneous decrease in the serum levels of soluble VCAM-1 and S100 within the first 24 hours after the return of spontaneous circulation was associated with a good neurological outcome in out-of-hospital cardiac arrest survivors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood-Brain Barrier
/
S100 Proteins
/
Cell Adhesion Molecules
/
Cell Adhesion
/
Prospective Studies
/
Retrospective Studies
/
Cardiopulmonary Resuscitation
/
Survivors
/
Intercellular Adhesion Molecule-1
/
Vascular Cell Adhesion Molecule-1
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Clinical and Experimental Emergency Medicine
Year:
2018
Type:
Article
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