Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 289-292, 2018.
Article
in English
| WPRIM
| ID: wpr-718877
ABSTRACT
OBJECTIVES:
Chronic periodontitis is a common inflammatory disease of the oral cavity that causes destruction of periodontal tissues and bone around the teeth. Sclerostin is a protein encoded by the SOST gene. In this study, gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis were compared with those of healthy subjects. MATERIALS ANDMETHODS:
In this case-control study, a total of 40 subjects were enrolled and divided into the healthy group (n=23) and chronic periodontitis group (n=17). GCF samples were collected, and the concentration of sclerostin was evaluated using enzyme-linked immunosorbent assay. Comparison of significance between groups was assessed using Mann-Whitney U test.RESULTS:
Sclerostin concentration was significantly higher in the chronic periodontitis group compared with the healthy group (P < 0.005).CONCLUSION:
Despite the limitations of this study, sclerostin can be a possible marker for assessment of periodontal health status.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontitis
/
Tooth
/
Enzyme-Linked Immunosorbent Assay
/
Case-Control Studies
/
Gingival Crevicular Fluid
/
Chronic Periodontitis
/
Healthy Volunteers
/
Mouth
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS