Shorter Telomere Length Is Associated with Increased Breast Cancer Risk in a Chinese Han Population: A Case-Control Analysis / 한국유방암학회지
Journal of Breast Cancer
;
: 391-398, 2018.
Article
in English
| WPRIM
| ID: wpr-718894
ABSTRACT
PURPOSE:
The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length.METHODS:
We used real-time quantitative polymerase chain reaction to measure relative telomere length (RTL) in genomic DNA extracted from peripheral blood from 183 breast cancer cases and 191 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform.RESULTS:
Our results show that breast cancer patients had significantly shorter RTLs than control subjects (p 40 years (OR, 2.41; 95% CI, 1.31–4.43; p=0.005), body mass index ≤24 kg/m2 (OR, 2.81; 95% CI, 1.55–5.10; p=0.001), and postmenopausal women (OR, 3.94; 95% CI, 1.63–9.51; p=0.002), respectively. In addition, individuals with the AA genotype of rs2853677 have longer telomeres than those of breast cancer patients with the AG genotype (p=0.011).CONCLUSION:
Our results suggest that shorter RTL was associated with an increased risk of breast cancer. An association was found between the AA genotype of rs2853677 and longer RTLs in the case group. Functional studies are warranted to validate this association and further investigate our findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast
/
Breast Neoplasms
/
DNA
/
Body Mass Index
/
Case-Control Studies
/
Polymerase Chain Reaction
/
Telomere
/
Telomerase
/
Asian People
/
Real-Time Polymerase Chain Reaction
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Breast Cancer
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS