Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes / 한국실험동물학회지
Laboratory Animal Research
;
: 147-159, 2018.
Article
in English
| WPRIM
| ID: wpr-719079
ABSTRACT
Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used as an integral experimental tool for generating the conditional. This system has enabled researchers to investigate genes of interest in a tissue/cell (spatial control) and/or time (temporal control) specific manner. A various tissue-specific Cre-driver mouse lines have been generated to date, and new Cre lines are still being developed. This review provides a brief overview of Cre-loxP system and a few commonly used promoters for expression of tissue-specific Cre recombinase. Also, we finally introduce some available links to the Web sites that provides detailed information about Cre mouse lines including their characterization.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recombinases
Limits:
Animals
/
Humans
Language:
English
Journal:
Laboratory Animal Research
Year:
2018
Type:
Article
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