The age-adjusted Charlson comorbidity index as a predictor of survival in surgically treated vulvar cancer patients / 부인종양
Journal of Gynecologic Oncology
;
: e6-2019.
Article
in English
| WPRIM
| ID: wpr-719246
ABSTRACT
OBJECTIVE:
To evaluate the impact of age-adjusted Charlson comorbidity index (ACCI) in predicting disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) among surgically treated patients with vulvar carcinoma. The secondary aim is to evaluate its impact as a predictor of the pattern of recurrence.METHODS:
We retrospectively evaluated data of patients that underwent surgical treatment for vulvar cancer from 1998 to 2016. ACCI at the time of primary surgery was evaluated and patients were classified as low (ACCI 0–1), intermediate (ACCI 2–3), and high risk (>3). DFS, OS and CSS were analyzed using the Kaplan-Meir and the Cox proportional hazard models. Logistic regression model was used to assess predictors of distant and local recurrence.RESULTS:
Seventy-eight patients were included in the study. Twelve were classified as low, 36 as intermediate, and 30 as high risk according to their ACCI. Using multivariate analysis, ACCI class was an independent predictor of worse DFS (hazard ratio [HR]=3.04; 95% confidence interval [CI]=1.54–5.99; p < 0.001), OS (HR=5.25; 95% CI=1.63–16.89; p=0.005) and CSS (HR=3.79; 95% CI=1.13–12.78; p=0.03). Positive nodal status (odds ratio=8.46; 95% CI=2.13–33.58; p=0.002) was the only parameter correlated with distant recurrence at logistic regression.CONCLUSION:
ACCI could be a useful tool in predicting prognosis in surgically treated vulvar cancer patients. Prospective multicenter trials assessing the role of ACCI in vulvar cancer patients are warranted.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Vulvar Neoplasms
/
Comorbidity
/
Logistic Models
/
Proportional Hazards Models
/
Multivariate Analysis
/
Prospective Studies
/
Retrospective Studies
/
Multicenter Studies as Topic
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Humans
Language:
English
Journal:
Journal of Gynecologic Oncology
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS