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Omitting Adjuvant Radiotherapy for Hormone Receptor‒Positive Early-Stage Breast Cancer in Old Age: A Propensity Score Matched SEER Analysis / Journal of the Korean Cancer Association, 대한암학회지
Article in English | WPRIM | ID: wpr-719331
Responsible library: WPRO
ABSTRACT

PURPOSE:

The purpose of this study was to investigate the non-inferiority of omitting radiotherapy (RT) after breast-conserving surgery (BCS) for hormone receptor (HR)‒positive T1N0 breast cancer in elderly women. MATERIALS AND

METHODS:

From 2004 to 2014, HR-positive T1N0 breast cancer patients aged 50 years or older and receiving BCS were retrieved from the Surveillance, Epidemiology, and End

RESULTS:

18 database. After propensity score matching between the no-RT and RT groups, univariate and multivariate analyses were performed. Identified prognostic factors were used to stratify the risk groups. In each risk group, 10-year cancer-specific survival (CSS) rates were compared between the no-RT and RT groups.

RESULTS:

After propensity score matching, the numbers of patients in the no-RT and RT groups were both 18,586. For patients who satisfied both a tumor size of 1-10 mm and a tumor grade of 1-2, omitting RT did not decrease the CSS rate at any age group, ranging from ≥ 50 to ≥ 85 years; for patients aged ≥ 50 years, the 10-year CSS rates in the no-RT and RT groups were 97.2% and 96.8%, respectively (adjusted hazard ratio, 0.862; p=0.312). However, for patients with a tumor size of 11-20 mm or tumor grade of 3-4, RT significantly increased the CSS rate irrespective of age.

CONCLUSION:

RT after BCS for HR-positive T1N0 breast cancer in elderly women might be omitted without causing a decrease in the CSS rate, but only in patients who satisfy both a small tumor size (≤ 10 mm) and low tumor grade (1-2).
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiotherapy / Breast / Breast Neoplasms / Aged / Female / Humans / Mastectomy, Segmental / Receptors, Progesterone / Receptors, Estrogen / Epidemiology Language: English Journal: Cancer Research and Treatment Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiotherapy / Breast / Breast Neoplasms / Aged / Female / Humans / Mastectomy, Segmental / Receptors, Progesterone / Receptors, Estrogen / Epidemiology Language: English Journal: Cancer Research and Treatment Year: 2019 Type: Article