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Leptospirosis as Unusual Trigger of Systemic Lupus Erythematosus
Article in En | WPRIM | ID: wpr-719457
Responsible library: WPRO
ABSTRACT
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder of an unknown origin. The role of leptospirosis as a triggering factor for SLE is unknown. This paper reports an uncommon case of SLE following a leptospira infection. A 29-year-old female was referred due to fevers, myalgia, and facial edema with rash. Laboratory investigations revealed a hepatic dysfunction, significantly raised lactate dehydrogenase with marked leukopenia and thrombocytopenia. A diagnosis of leptospirosis was confirmed. The patient was treated with antibiotic therapy for leptospirosis. She developed dyspnea after one week. The echocardiogram revealed global hypokinesia with a decreased ejection fraction. A positivity of antinuclear, anti-DNA, and anti-Smith antibodies, together with clinical and laboratory improvement by steroid therapy, led to the diagnosis of SLE. This case highlights the presence of concurrent SLE and leptospirosis. As the symptoms of SLE are similar to leptospirosis, accurate diagnosis through high suspicion is essential for appropriate treatment.
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Full text: 1 Index: WPRIM Main subject: Thrombocytopenia / Hypokinesia / Diagnosis / Dyspnea / Edema / Exanthema / Fever / Myalgia / L-Lactate Dehydrogenase / Leptospira Type of study: Diagnostic_studies Limits: Adult / Female / Humans Language: En Journal: Journal of Rheumatic Diseases Year: 2019 Type: Article
Full text: 1 Index: WPRIM Main subject: Thrombocytopenia / Hypokinesia / Diagnosis / Dyspnea / Edema / Exanthema / Fever / Myalgia / L-Lactate Dehydrogenase / Leptospira Type of study: Diagnostic_studies Limits: Adult / Female / Humans Language: En Journal: Journal of Rheumatic Diseases Year: 2019 Type: Article