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Risk Factors of Behavioral and Psychological Symptoms in Patients with Alzheimer Disease: The Clinical Research of Dementia of South Korea Study / 가정의학회지
Korean Journal of Family Medicine ; : 16-21, 2019.
Article in English | WPRIM | ID: wpr-719538
ABSTRACT

BACKGROUND:

Few studies have evaluated risk factors for behavioral and psychological symptoms of dementia at the initial assessment for Alzheimer disease in large patient samples. In this study, the factors influencing Alzheimer disease were examined using the Clinical Research of Dementia of South Korea data.

METHODS:

This cross-sectional study was conducted using data of 1,128 patients with Alzheimer disease. The behavioral and psychological symptoms of dementia were examined using the Korean version of the Neuropsychiatric Inventory. Demographic characteristics, health-related behavior, neuropsychological tests, comorbidities, blood test results, and caregiver characteristics were assessed. Median logistic regression analysis with adjustment for covariates was conducted.

RESULTS:

The behavioral and psychological symptoms of dementia were negatively associated with memory (P=0.022) and frontal/executive (P < 0.001) function in the Seoul Neuropsychological Screening Battery-dementia, Barthel Index for Activities of Daily Living (P < 0.001), Korean version of the Mini-Mental State Examination score (P=0.003), and caregiver age (P=0.005) after adjustment for confounding factors, and positively associated with the Seoul-Instrumental Activities of Daily Living score (P < 0.001), Clinical Dementia Rating Sum of Box (P < 0.001), Global Deterioration Scale score (P < 0.001), abnormality of free T4 level (P < 0.001), anemia (P < 0.001), and family history of stroke (P=0.001). Patients with female caregivers exhibited more severe behavioral and psychological symptoms of dementia than those with male caregivers.

CONCLUSION:

Behavioral and psychological symptoms of dementia in Alzheimer disease patients were associated with various risk factors including the inability to live independently and Alzheimer disease severity. These findings suggest that prevention and treatment strategies for the behavioral and psychological symptoms of dementia should be comprehensive.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Behavioral Symptoms / Activities of Daily Living / Comorbidity / Logistic Models / Mass Screening / Cross-Sectional Studies / Risk Factors / Caregivers / Stroke / Dementia Type of study: Diagnostic study / Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Korean Journal of Family Medicine Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Behavioral Symptoms / Activities of Daily Living / Comorbidity / Logistic Models / Mass Screening / Cross-Sectional Studies / Risk Factors / Caregivers / Stroke / Dementia Type of study: Diagnostic study / Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Korean Journal of Family Medicine Year: 2019 Type: Article