A Randomized Clinical Trial of Synbiotics in Irritable Bowel Syndrome: Dose-Dependent Effects on Gastrointestinal Symptoms and Fatigue / 가정의학회지
Korean Journal of Family Medicine
;
: 2-8, 2019.
Article
in English
| WPRIM
| ID: wpr-719540
ABSTRACT
BACKGROUND:
This double-blind, randomized controlled design study aimed to assess the dose-dependent effects of synbiotics on gastrointestinal symptoms of and fatigue in irritable bowel syndrome (IBS).METHODS:
Thirty subjects with IBS were randomly assigned into the following three groups and received 2 capsules a day for 8 weeks (1) high-dose (2 capsules of synbiotics); (2) low-dose (1 capsule of synbiotics and 1 capsule of placebo); and (3) placebo (2 capsules of placebo). At baseline and 8 weeks, they completed the study questionnaires.RESULTS:
Two subjects in the high-dose group were lost to follow-up, leaving a total of 28 patients for the analysis. After 8 weeks, abdominal discomfort, abdominal bloating, frequency of formed stool, fatigue Visual Analog Scale (VAS), and Multidimensional Fatigue Inventory were significantly different among the groups (P=0.002, 0.006, 0.007, 0.028, and 0.041, respectively, by Kruskal-Wallis test). However, only abdominal discomfort, abdominal bloating, frequency of formed stool, and fatigue VAS were significantly improved in the high-dose group compared with those in the placebo group (P=0.002, 0.003, 0.002, and 0.013, respectively) by Mann-Whitney test with Bonferroni correction. No adverse drug reactions were reported.CONCLUSION:
High-dose synbiotics were superior to placebo in improving bowel symptoms and fatigue of IBS patients, suggesting that synbiotic dosage plays an important role in the treatment of IBS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Capsules
/
Probiotics
/
Irritable Bowel Syndrome
/
Drug-Related Side Effects and Adverse Reactions
/
Fatigue
/
Lost to Follow-Up
/
Synbiotics
/
Visual Analog Scale
Type of study:
Controlled clinical trial
/
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Family Medicine
Year:
2019
Type:
Article
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