Effect of Korean Herbal Formula (Modified Ojayeonjonghwan) on Androgen Receptor Expression in an Aging Rat Model of Late Onset Hypogonadism
The World Journal of Men's Health
;
: 105-112, 2019.
Article
in English
| WPRIM
| ID: wpr-719624
ABSTRACT
PURPOSE:
Testosterone replacement therapy is an effective treatment for late-onset hypogonadism (LOH) despite a few contraindications and side-effects. The aim of this study was to determine whether modified Ojayeonjonghwan (KH-204, Korean herbal formula) improved LOH. KH-204 is a strong antioxidant herbal formula. We evaluated the effect of Korean herbal prescription on androgen receptor (AR) expression in an aged rat model of LOH. MATERIALS ANDMETHODS:
Eighteen-month-old rats were used as aged LOH rat models. Eighteen Sprague-Dawley rats were randomly divided into three equal groups of six animals each and treated with one of the following 1) normal control group (oral administration with distilled water, n=6), 2) KH-204 200 group (oral administration with 200 mg/kg of KH-204, n=6), and 3) KH-204 400 group (oral administration with 400 mg/kg of KH-204, n=6). After four weeks of treatment (once daily, distilled water or KH-204), serum testosterone levels, changes in testicular and epididymal weight, Western blotting analysis of AR expression and measurement of oxidative stress were examined.RESULTS:
Treatment with the herbal formulation KH-204 200 mg/kg and 400 mg/kg (1) increased the weights of testis and epididymis; (2) increased the level of serum testosterone; (3) increased the level of superoxide dismutase and reduced the level of 8-hydroxy-20-deoxyguanosine; and (4) upregulated AR expression in testicular tissue.CONCLUSIONS:
KH-204 might be an effective alternative for LOH. It improves antioxidant mechanisms and increases testicular AR expression without side-effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Superoxide Dismutase
/
Testis
/
Testosterone
/
Weights and Measures
/
Aging
/
Water
/
Receptors, Androgen
/
Blotting, Western
/
Rats, Sprague-Dawley
/
Oxidative Stress
Limits:
Animals
Language:
English
Journal:
The World Journal of Men's Health
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS