Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 80-89, 2019.
Article
in English
| WPRIM
| ID: wpr-719716
ABSTRACT
PURPOSE:
In the presence of interferon, proteasome subunits are replaced by their inducible counterparts to form an immunoproteasome (IP) plays a key role in generation of antigenic peptides presented by MHC class I molecules, leading to elicitation of a T cell‒mediated immune response. Although the roles of IP in other cancers, and inflammatory diseases have been extensively studied, its significance in breast cancer is unclear. MATERIALS ANDMETHODS:
We investigated the expression of LMP7, an IP subunit, and its relationship with immune system components in two breast cancer cohorts.RESULTS:
In 668 consecutive breast cancer cohort, 40% of tumors showed high level of LMP7 expression, and tumors with high expression of LMP7 had more tumor-infiltrating lymphocytes (TILs) in each subtype of breast cancer. In another cohort of 681 triple-negative breast cancer patients cohort, the expression of LMP7 in tumor cells was significantly correlated with the amount of TILs and the expression of interferon-associated molecules (MxA [p < 0.001] and PKR [p < 0.001]), endoplasmic reticulum stress-associated molecules (PERK [p=0.012], p-eIF2a [p=0.001], and XBP1 [p < 0.001]), and damage-associated molecular patterns (HMGN1 [p < 0.001] and HMGB1 [p < 0.001]). Patients with higher LMP7 expression had better disease-free survival outcomes than those with no or low expression in the positive lymph node metastasis group (p=0.041).CONCLUSION:
Close association between the TIL levels and LMP7 expression in breast cancer indicates that better antigen presentation through greater LMP7 expression might be associated with more TILs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Breast
/
Breast Neoplasms
/
Cohort Studies
/
Lymphocytes, Tumor-Infiltrating
/
Interferons
/
Antigen Presentation
/
Disease-Free Survival
/
HMGB1 Protein
/
Proteasome Endopeptidase Complex
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2019
Type:
Article
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