The Effect of Apolipoprotein E Polymorphism on Hypertension in Korean Adults / 農村醫學 地域保健

ABSTRACT

BACKGROUND: Apolipoprotein E has been one of the most thoroughly studied genetic polymorphisms, particularly for its effects on lipid profiles and coronary heart disease risk. This study investigated the relationship between the apolipoprotein E polymorphism and essential hypertension in a Korean population. METHODS: The subjects (n=1,243) were participants in a population-based study in Incheon metropolitan City, Korea. The apolipoprotein E polymorphism was determined using a polymerase chain reaction method. RESULTS: The frequencies of the genotypes did not differ significantly between the hypertensive groups (60.0% epsilon2/epsilon2, 30.8% epsilon2/epsilon3, 44.4% epsilon2/epsilon4, 33.3% epsilon3/epsilon3, 32.3% epsilon3/epsilon4, and 15.4% epsilon4/epsilon4; p=0.498). After adjusting for other risk factors, genotypes were not associated with hypertension(OR 5.74, 95% CI 0.81-40.76, epsilon2/epsilon2 vs. epsilon3/epsilon3; OR 0.94, 95% CI 0.60-1.47, epsilon2/epsilon3 vs. epsilon3/epsilon3; OR 1.21, 95% CI 0.30-4.89, epsilon2/epsilon4 vs. epsilon3/epsilon3; OR 0.79, 95% CI 0.56-1.13, epsilon3/epsilon4 vs. epsilon3/epsilon3; OR 0.29, 95% CI 0.06-1.45, epsilon4/epsilon4 vs. epsilon3/epsilon3). CONCLUSIONS: These findings suggest that the apolipoprotein E polymorphism is not associated with hypertension.