Acquired von Willebrand Syndrome Associated with Amyloidosis / 대한혈액학회지
Korean Journal of Hematology
;
: 310-314, 2009.
Article
in Korean
| WPRIM
| ID: wpr-720066
ABSTRACT
Acquired von Willebrand syndrome (AvWS) is a relatively rare acquired bleeding disorder similar to inherited von Willebrand disease in terms of laboratory findings, and occurs without a personal or family history of bleeding. A 23-year-old man with no previous disease history and no family history of hemorrhagic diathesis was referred to our hospital because of recurrent epistaxis and intramuscular hematoma. He was diagnosed as having AvWS because of an almost complete absence of ristocetin cofactor activity (vWF RCo) despite normal vWF antigen level. Furthermore, anti-vWF antibody was detected in his serum using home-brewed ELISA. Finally, the amyloid deposit was found in muscle biopsy. He was diagnosed with AvWS which is associated with amyloidosis. AvWS should be considered in patients with current bleeding diatheses and no past history of bleeding.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Von Willebrand Diseases
/
Biopsy
/
Von Willebrand Factor
/
Enzyme-Linked Immunosorbent Assay
/
Epistaxis
/
Plaque, Amyloid
/
Disease Susceptibility
/
Hematoma
/
Hemorrhage
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Hematology
Year:
2009
Type:
Article
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