Galectin-8 Expression in Laryngeal Squamous Cell Carcinoma
Clinical and Experimental Otorhinolaryngology
;
: 13-19, 2009.
Article
in English
| WPRIM
| ID: wpr-72009
ABSTRACT
OBJECTIVES:
Despite the ongoing development of treatment protocols for laryngeal squamous cell carcinoma (LSCC), the patients suffering with this malady have shown only a modestly improved outcome. This poor outcome has been attributed to the lack of therapy that's individualized to the tumor's biological properties. Various studies have showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues, and the level of the galectin-8 expression may correlate with the malignancy of human squamous cell carcinoma. The purpose of this study is to evaluate the expression of galectin-8 and to investigate its correlations with the primary stage, the nodal involvement, the clinical stage and the histologic grade of squamous cell carcinoma of the larynx.METHODS:
The paraffin-embedded tissue specimens from 77 patients who were diagnosed as LSCC between 1993 and 2007 were immunohistochemically stained for galectin-8.RESULTS:
Immunohistochemical analysis showed that a strong positive expression of galectin-8 was correlated with the T-stages, the nodal stages and the clinical stages. However, the histopathologic grades were not correlated with the galectin-8 expression in LSCC.CONCLUSION:
The expression of galectin-8 protein can be used as a prognostic factor for patients with LSCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stress, Psychological
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Clinical Protocols
/
Larynx
Type of study:
Practice guideline
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clinical and Experimental Otorhinolaryngology
Year:
2009
Type:
Article
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