The Clinical Guidelines for Myelodysplastic Syndrome / 대한혈액학회지
Korean Journal of Hematology
;
: 71-90, 2007.
Article
in Korean
| WPRIM
| ID: wpr-720133
ABSTRACT
The myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis associated with multilineage cytopenias leading to serious morbidity or mortality, and the additional risk of leukemic transformation. The management of patients with MDS can be very complex and varies according to both the clinical manifestations in individual patients as well as the presence of complicating medical conditions. However, therapeutic dilemmas still exist for MDS due to the multifactorial pathogenetic features of the disease, its heterogeneous stages, and the elderly patient population. For these reasons, proper guidelines for management are necessary. This review describes the proper diagnosis for MDS, decision-making approaches for optimal therapeutic options that are based on a consideration of patient clinical factors and risk-based prognostic categories, and the use of recently available biospecific drugs such as hypomethylating agents that are potentially capable of abrogating the abnormalities associated with MDS. Proper indications and methods for transplantation, response criteria, management for iron overload for highly transfused patients and specific considerations for MDS in childhood are also described. All of these topics were discussed at the third symposium of AML/MDS working party on 3 March, 2007.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation
/
Myelodysplastic Syndromes
/
Mortality
/
Iron Overload
/
Diagnosis
/
Hematopoiesis
Type of study:
Diagnostic study
/
Practice guideline
/
Prognostic study
Limits:
Aged
/
Humans
Language:
Korean
Journal:
Korean Journal of Hematology
Year:
2007
Type:
Article
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