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Primary cutaneous B-cell lymphoblastic lymphoma in an elderly man / 대한혈액학회지
Korean Journal of Hematology ; : 283-286, 2011.
Article in English | WPRIM | ID: wpr-720151
ABSTRACT
Precursor B-cell lymphoblastic lymphoma (B-LBL) is an uncommon high-grade neoplasm of immature B cells. It occurs predominantly in childhood with extranodal involvement such as skin and bone. Therefore, primary cutaneous involvement in elderly adults is a very rare manifestation of B-LBL. Here, we report a 78-year-old man with B-LBL presenting as a single cutaneous lesion which was immunohistochemically positive for leukocyte common antigen (LCA), CD79a, paired box 5 (PAX5), B cell lymphoma-2 (bcl-2), and terminal deoxynucleotidyl transferase (TdT) staining, but was without systemic involvement. The patient was treated using cyclophosphamide, adriamycin, vincristine, and prednisolone (CHOP), and achieved complete response (CR) at the first response assessment conducted after 3 CHOP cycles. After an additional cycle of CHOP treatment, radiotherapy was administered at a total dose of 3,600 cGy over 4 weeks. At the 21-month follow-up, he had maintained CR.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Vincristine / Prednisolone / B-Lymphocytes / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Doxorubicin / Follow-Up Studies / Leukocyte Common Antigens / Cyclophosphamide / DNA Nucleotidylexotransferase Type of study: Observational study / Prognostic study Limits: Adult / Aged / Humans Language: English Journal: Korean Journal of Hematology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Vincristine / Prednisolone / B-Lymphocytes / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Doxorubicin / Follow-Up Studies / Leukocyte Common Antigens / Cyclophosphamide / DNA Nucleotidylexotransferase Type of study: Observational study / Prognostic study Limits: Adult / Aged / Humans Language: English Journal: Korean Journal of Hematology Year: 2011 Type: Article