The effectiveness of tacrolimus and minidose methotrexate in the prevention of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in children: a single-center study in Korea / 대한혈액학회지
Korean Journal of Hematology
;
: 113-118, 2012.
Article
in English
| WPRIM
| ID: wpr-720204
ABSTRACT
BACKGROUND:
Knowledge of the roles of tacrolimus and minidose methotrexate (MTX) in the prevention of acute graft-versus-host disease (aGVHD) in pediatric allogeneic hematopoietic stem cell transplantation (HSCT) is limited. We retrospectively evaluated the engraftment status, incidence of aGVHD and chronic GVHD (cGVHD), and toxicities of tacrolimus and minidose MTX in aGVHD prophylaxis in children undergoing allogeneic HSCT.METHODS:
Seventeen children, who underwent allogeneic HSCT and received tacrolimus and minidose MTX as GVHD prophylaxis from March 2003 to February 2011, were reviewed retrospectively. All the patients received tacrolimus since the day before transplantation at a dose of 0.03 mg/kg/day and MTX at a dose of 5 mg/m2 on days 1, 3, 6, and 11.RESULTS:
Of the 17 patients, 9 received human leukocyte antigen (HLA)-matched related donor transplants, and 8 received HLA-matched, or partially mismatched unrelated donor transplants. The median time for follow-up was 55 months. The incidence of aGVHD in the related and unrelated donor groups was 22.2% and 42.9%, respectively. cGVHD was not observed. To maintain therapeutic blood levels of tacrolimus, the younger group ( or =8 years) (P=0.0075). The adverse events commonly associated with tacrolimus included hypomagnesemia (88%), nephrotoxicity (23%), and hyperglycemia (23%).CONCLUSION:
Tacrolimus and minidose MTX were well tolerated and effective in GVHD prophylaxis in pediatric patients undergoing allogeneic HSCT. Children <8 years of age undergoing HSCT required increased doses of tacrolimus to achieve therapeutic levels.
Full text:
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Index:
WPRIM (Western Pacific)
Main subject:
Tissue Donors
/
Hematopoietic Stem Cells
/
Methotrexate
/
Incidence
/
Retrospective Studies
/
Follow-Up Studies
/
Tacrolimus
/
Hematopoietic Stem Cell Transplantation
/
Transplants
/
Unrelated Donors
Type of study:
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Journal of Hematology
Year:
2012
Type:
Article
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