Response to Immunosuppressive Therapy and an HLA-DR Allele in Children with Aplastic Anemia / 대한혈액학회지
Korean Journal of Hematology
;
: 36-42, 1999.
Article
in Korean
| WPRIM
| ID: wpr-720259
ABSTRACT
BACKGROUND:
Genetic susceptibility to a variety of disease has been shown and it has recently been suggested that aplastic anemia is more common in adults who are HLA-DR2+ than in the general population.METHODS:
To investigate whether certain HLA-DR gene is more common in children with aplastic anemia and HLA-DR2+ gene is associated with susceptibility to cyclosporine A (CyA), we analyzed the results of HLA-DR typing in 37 children with aplastic anemia with sequence specific oligonucleotide probe (SSOP) method.RESULTS:
Eight patients were DR2+, and there was no more common than the normal population. All of the 8 patients with DR2+ were DRB1*1501+ with high resolution HLA typing. Of the 8 patients with DRB1*1501+, 3 patients were treated with CyA alone (2 patients) or CyA plus ATG (1 patient), 2 patients were treated with ATG (1 patient) or ALG alone (1 patient). Patients treated with CyA only or CyA plus ATG had either a complete (1 patient) or partial (2 patients) response and patients treated ATG or ALG alone had no response.CONCLUSION:
Although incidence of HLA-DR2 was not significantly higher in children with aplastic anemia then normal population, response rate to CyA was significantly high in the DR2+ patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Histocompatibility Testing
/
HLA-DR Antigens
/
HLA-DR2 Antigen
/
Incidence
/
Cyclosporine
/
Genetic Predisposition to Disease
/
Alleles
/
Anemia, Aplastic
Type of study:
Incidence study
/
Prognostic study
Limits:
Adult
/
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Hematology
Year:
1999
Type:
Article
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