A variant acute promyelocytic leukemia with t(11;17) (q23;q12); ZBTB16-RARA showing typical morphology of classical acute promyelocytic leukemia
Korean Journal of Hematology
; : 133-135, 2010.
Article
in En
| WPRIM
| ID: wpr-720268
Responsible library:
WPRO
ABSTRACT
A subgroup of acute leukemia with morphology resembling acute promyelocytic leukemia (APL) shows variant translocations involving RARA and has a different morphology from that of classical APL. The variant APL with t(11;17)(q23;q12); ZBTB16-RARA subgroup has been reported to have leukemic cells with regular nuclei, many granules, absence of Auer rods, an increased number of Pelgeroid neutrophils, strong myeloperoxidase (MPO) activity, and all-trans-retinoic-acid (ATRA) resistance. Here, we report a case of variant APL with t(11;17)(q23;q12); ZBTB16-RARA showing typical morphological features of classical APL, including numerous Auer rods and faggot cells. The leukemic cells expressed CD13, CD33, CD117, human leukocyte antigen (HLA)-DR, and cytoplasmic-MPO on the immunophenotyping study. The diagnosis was confirmed by cytogenetic and molecular studies. To distinguish variant APL cases from classical APL cases, regardless of whether morphologically the findings are consistent with those of classical APL, combining morphologic, immunophenotypic, cytogenetic, and molecular studies before chemotherapy is very important.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Leukemia, Promyelocytic, Acute
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Leukemia
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Immunophenotyping
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Peroxidase
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Cytogenetics
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Leukocytes
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Neutrophils
Limits:
Humans
Language:
En
Journal:
Korean Journal of Hematology
Year:
2010
Type:
Article