Multiple Chromosomal Abnormalities Accompanying Disseminated Granulocytic Sarcoma in Recurrent Acute Myelogenous Leukemia 50,XY,+8,+10,del(15)(q13),+21,+22 / 대한혈액학회지

ABSTRACT

It is known that acute myelogenous leukemia (AML) carries chromosomal abnormalities in 55-78% of patients, and that chromosomal abnormalities were associated with pathophysiology of disease, clinical feature, and it's prognosis. Granulocytic sarcoma occurring in 2~14% of AML is especially associated with t(8;21), is common to misdiagnose as malignant lymphoma, and has poor prognosis as survival of 5.4 months due to poor response to chemotherapy. Hereby we report a case of recurrent AML occurred as granulocytic sarcoma carring multiple chromosomal aberration without accompanying t(8;21).