Bortezomib Therapy Followed by Autologous Stem Cell Transplantation in POEMS Syndrome / 대한혈액학회지
Korean Journal of Hematology
;
: 145-149, 2008.
Article
in English
| WPRIM
| ID: wpr-720518
ABSTRACT
BACKGROUND:
The acronym POEMS refers to polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. Increased levels of cytokines, including vascular endothelial growth factor (VEGF), appear to play a pathogenic role. POEMS syndrome is progressive and eventually leads to death from neurological problem without therapy.METHODS:
We treated 3 patients affected by POEMS syndrome with front-line bortezomib treatment and the high-dose melphalan with autologous stem cell transplantation (ASCT).RESULTS:
Bortezomib reduced circulating levels of VEGF in sera. After a median follow-up of 18 months (range, 16~20), all patients are alive with progressive improvement in neurological disease, skin changes, performance status and have no evidence of clonal plasmacytosis or organomegaly.CONCLUSION:
ASCT following bortezomib treatment may be a potential treatment option for patients with POEMS syndrome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyneuropathies
/
Pyrazines
/
Skin
/
Skin Diseases
/
Stem Cells
/
Boronic Acids
/
Follow-Up Studies
/
Cytokines
/
POEMS Syndrome
/
Peripheral Nervous System Diseases
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Hematology
Year:
2008
Type:
Article
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