Efficacy and Safety of Short-term Administration of Rifaximin in the Treatment of Hepatic Encephalopathy / 대한간학회지
The Korean Journal of Hepatology
;
: 55-60, 2001.
Article
in Korean
| WPRIM
| ID: wpr-72055
ABSTRACT
BACKGROUND/AIMS:
A prospective, randomized study was performed to evaluate the efficacy and safety of the short-term administration of rifaximin in the treatment of hepatic encephalopathy.METHODS:
Of the 64 patients diagnosed as having decompensated liver cirrhosis with hepatic encephalopathy, 39 patients were randomized to receive rifaximin and 25 patients to receive lactulose for seven days. Before and after the treatment we assessed changes in the level of serum ammonia, flapping tremor, patient's mental status, number connection test (NCT), and hepatic encephalopathy indices.RESULTS:
In rifaximin-treated group, the mean grade of serum ammonia (1.8->0.9), mental status (1.3->0.3), NCT (3.0->2.0), and flapping tremor (1.7->0.4) were improved after treatment. In the lactulose-treated group, the mean grade of serum ammonia (1.9->1.0), mental status (1.5->0.5), NCT (3.3->2.1), and flapping tremor (1.4->0.3) were improved after treatment. Side effects of abdominal pain (rifaximin group) and excessive diarrhea (lactulose group) were noted in 2 cases. The efficacy of treatment was not significantly different between rifaximin and lactulose-treated groups (84.3% vs. 95.3%).CONCLUSION:
Rifaximin was as efficient and safe in the treatment of hepatic encephalopathy as lactulose in terms of efficacy. Rifaximin may be useful drug for the short-term treatment of hepatic encephalopathy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tremor
/
Abdominal Pain
/
Hepatic Encephalopathy
/
Prospective Studies
/
Diarrhea
/
Ammonia
/
Lactulose
/
Liver Cirrhosis
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Hepatology
Year:
2001
Type:
Article
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