A Case of B-Prolymphocytic Leukemia / 대한혈액학회지
Korean Journal of Hematology
;
: 123-128, 1997.
Article
in Korean
| WPRIM
| ID: wpr-720572
ABSTRACT
Prolymphocytic leukemia (PLL) is a member of chronic lymphoproliferative disorders with relatively distinct clinical, morphologic, immunologic and prognostic features. The diagnosis of PLL is determined by more than 55% of prolymphocytes in the peripheral blood. It is characterized by leukocytosis, massive splenomegaly with little or no lymphadenopathy, and male prevalence. In immunophenotyping, the majority (80%) of the cases express B cell markers and the rest (20%), T cell type. We experienced a case of B-PLL. The patient was a 65 year-old man who presented with marked leukocytosis (110.5x109/L) and 78% of characteristic prolymphocytes in the peripheral blood. The bone marrow aspirate showed 13.6% of prolymphocytes and coarse granular positivity of prolymphocytes in PAS stain. The immunophenotyping of the leukemic prolymphocytes revealed the positivity of surface immunoglobulin (IgM, lambda type), HLA- DR and CD19. The monoclonal gammopathy (IgM, lambda type) was also detectable in the patient's serum.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraproteinemias
/
Splenomegaly
/
Bone Marrow
/
Immunoglobulins
/
Leukemia, Prolymphocytic
/
Leukemia
/
Prevalence
/
Immunophenotyping
/
Diagnosis
/
Leukocytosis
Type of study:
Diagnostic study
/
Prevalence study
/
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Hematology
Year:
1997
Type:
Article
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