The immunobiology of cord blood transplantation / 대한혈액학회지
Korean Journal of Hematology
;
: 224-235, 2010.
Article
in English
| WPRIM
| ID: wpr-720661
ABSTRACT
Despite significant recent advances in the applicability and outcome following unrelated cord blood transplantation (UCBT), infections remain a major cause of mortality associated with poor immune recovery in the first 6 months after UCBT. Enhanced immune reconstitution not only could improve survival by reduced transplant related mortality, but may also favorably impact on relapse incidence by improved graft-versus-leukemia effects. This review will summarize our current understanding of the biology of immune recovery post-UCBT with an emphasis on adaptive T cell dependent immunity. New efforts to boost immunity will be also highlighted including our own laboratory, where ex vivo T cell expansion is pursued towards adoptive immunotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Biology
/
Opportunistic Infections
/
Incidence
/
Immunotherapy, Adoptive
/
Transplants
/
Graft vs Leukemia Effect
/
Cord Blood Stem Cell Transplantation
/
Fetal Blood
Type of study:
Incidence study
/
Prognostic study
Language:
English
Journal:
Korean Journal of Hematology
Year:
2010
Type:
Article
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