Evaluation of Peripheral White Blood Cell Count or Monocyte Count to Guide Timing of Mobilized Stem Cell Collection in Patients with Breast Cancer / 대한혈액학회지

ABSTRACT

BACKGROUND: The optimal timing of peripheral blood stem cell (PBSC) collection is essential to successful procurement of sufficient PBSC for engraftment. The purpose of this study was to evaluate the peripheral blood parameters that may predict the apheretic yield of circulating stem cells in patients with breast cancer. METHODS: We did a retrospective review of 29 patients with breast cancer (14 high risk, 15 metastatic disease) who underwent mobilizing therapy from Dec. 1992 to Jan. 1999. Immediately prior to 119 consecutive PBSC collection procedures, the PB white blood cell (WBC) and monocyte were determined and correlated with stem cell parameters namely, CD34+ cell and mononuclear cell content. RESULTS: The median of 0.57x106CD34+cells/kg patient body weight (range, 0-9.39) were collected per harvest. The WBC on the day of apheresis showed only weak correlation with the mononuclear cells collected (r=0.26). In contrast, the WBC count and monocyte count in PB did not correlated with CD34+ cells harvested CONCLUSION: WBC and monocyte count are not appropriate parameters to identify the exact timing for apheresis and predict the amount of peripheral blood stem cells collected in patients with breast cancer.