Monoclonal Proteinuria as a Prognostic Factor for Multiple Myeloma Patients with Intact Immunoglobulin Type / 대한혈액학회지
Korean Journal of Hematology
;
: 276-282, 2007.
Article
in English
| WPRIM
| ID: wpr-720785
ABSTRACT
BACKGROUND:
Urine/serum protein electrophoresis (PEP) and immunofixation electrophoresis (IEP) for monoclonal protein (M-protein) are used for initial evaluation in patients with multiple myeloma. We evaluated the prognostic significance of M-proteinuria status and its association with other prognostic factors.METHODS:
Between December 2002 and December 2004, 64 de novo symptomatic multiple myeloma patients with intact immunoglobulin (Ig) type were divided into two groups according to their initial urine PEP/IEP findings.RESULTS:
Twenty-seven patients with undetectable or free light-chains only were classified into F group, and 37 with whole Ig with or without light-chains were classified into W group. The two groups were similar in sex, age, performance, azotemia, beta2-microglobulin, stage and treatment, but M-protein concentration was significantly higher in the W than in F group (5.1 vs 1.3g/dL, P<0.01). The overall response rate was significantly higher in F group than in W group (80.8% vs 63.6%, P=0.02), whereas the 2-year OS rate did not differ significantly between the groups (81.0% vs 57.7%, P=0.15).CONCLUSION:
Monoclonal proteinuria is helpful in identifying patients with advanced disease and poorer prognosis in multiple myeloma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Proteinuria
/
Immunoglobulins
/
Electrophoresis
/
Azotemia
/
Multiple Myeloma
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Hematology
Year:
2007
Type:
Article
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