FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype
Korean Journal of Hematology
;
: 250-257, 2007.
Article
in English
| WPRIM
| ID: wpr-720788
ABSTRACT
BACKGROUND:
The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance.METHODS:
The FLT3/ITD was studied by PCR assay in bone marrow samples obtained from 123 patients at diagnosis. Ninety patients who received intensive induction chemotherapy were evaluated.RESULTS:
Of total 123 patients, forty-seven (38.2%) demonstrated the aberrant FLT3/ITD. Patients with FLT3/ITD had significantly higher leukocyte counts at presentation than did patients without FLT3/ITD (P=0.04). By multivariate analysis, the FLT3/ITD was an independent prognostic factor of leukemic-free survival (LFS) (P=0.01) in AML patients with normal karyotype.CONCLUSION:
This study demonstrated that the presence of the FLT3/ITD was a significant factor for poor prognosis in AML patients with normal karyotype.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Bone Marrow
/
Leukemia, Myeloid, Acute
/
Polymerase Chain Reaction
/
Multivariate Analysis
/
Diagnosis
/
Induction Chemotherapy
/
Karyotype
/
Leukocyte Count
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Hematology
Year:
2007
Type:
Article
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