The Strategies for the Prevention of Chronic GVHD in Hematopoietic Stem Cell Transplantation / 대한혈액학회지
Korean Journal of Hematology
;
: 1-8, 2008.
Article
in English
| WPRIM
| ID: wpr-720819
ABSTRACT
Chronic graft-versus-host disease (GVHD) is the most frequent late complication after hematopoietic cell transplantation and has a major impact on the quality of life and survival. As the pathophysiology of GVHD is still incompletely understood, it has been difficult to design effective prophylactic regimens. However, prevention of acute GVHD appears to result in a lower incidence of chronic GVHD. The use of younger, non-allo-sensitized donors, preferentially of the same sex as the patient, and the use of stem cells other than G-CSF-mobilized peripheral blood stem cells, are associated with a decreased frequency of chronic GVHD. Further, the incorporation of thymoglobulin into the conditioning regimen has been demonstrated as beneficial to reduce chronic GVHD and delayed complications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Stem Cells
/
Tissue Donors
/
Hematopoietic Stem Cells
/
Incidence
/
Cell Transplantation
/
Hematopoietic Stem Cell Transplantation
/
Transplants
/
Graft vs Host Disease
/
Antilymphocyte Serum
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Hematology
Year:
2008
Type:
Article
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