A Case of Mixed-type Autoimmune Hemolytic Anemia / 대한혈액학회지

ABSTRACT

We report a case of mixed-type autoimmune hemolytic anemia in a 73-year-old female. At first, she visited at Pusan National University Hospital, complaining of dizziness and dyspnea for 3 months. Her hemoglobin level was 5.5g/dL, so red blood transfusion was requested by her physician. In ABO blood grouping, a discrepancy between cell and serum typing was observed. Also all of donor cells for crossmatching were reactive with patient's serum. High mean corpuscular volume (MCV) value was not normalized after warming. The cold agglutinin titer was 1 64 at 4degrees C, and was increased up to 1 1,024 at room temperature and 37degrees C, suggesting mixed-type autoimmune hemolytic anemia. The patient's symptoms and signs were improved progressively with corticosteroid therapy, and also ABO discrepancy was disappeared.