Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis / 한국역학회지
Epidemiology and Health
;
: e2015005-2015.
Article
in English
| WPRIM
| ID: wpr-721186
ABSTRACT
OBJECTIVES:
Although an expert review published in 2013 concluded that an association between human papillomavirus (HPV) infection and prostate cancer (PCa) risk had not yet been firmly established, a 2011 systematic review of 14 articles revealed an increased prevalence of HPV-16 DNA in PCa tissues. Another meta-analysis of the related articles is needed to evaluate the potential link between HPV infection and PCa risk.METHODS:
A snowballing search strategy was applied to the previously cited articles in the above-mentioned expert review and systematic review. Additional articles selected for this meta-analysis should fulfill all following inclusion criteria (a) evaluation of detected HPV-16 DNA in tissue samples and the PCa risk and (b) report of the HPV-16 prevalence in both cancer and control tissues. Estimated summary odds ratios (sOR) with 95% confidence intervals (CI) were calculated using fixed effect or random-effect models.RESULTS:
Hand searching identified 16 new articles. The sOR of the total 30 articles indicated a significant HPV-16 infection-related increase in the PCa risk (sOR, 1.851; 95% CI, 1.353 to 2.532, I2=37.82%).CONCLUSIONS:
These facts provide additional supportive evidence for a causal role of HPV-16 infection in prostate carcinogenesis. As the PCa incidence rates have increased rapidly in Asian countries, including Korea, during the last several decades, further studies of HPV-related PCa carcinogenesis may be necessary.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenic Viruses
/
Prostate
/
Prostatic Neoplasms
/
DNA
/
Passive Cutaneous Anaphylaxis
/
Odds Ratio
/
Incidence
/
Prevalence
/
Risk Factors
/
Asian People
Type of study:
Etiology study
/
Incidence study
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Epidemiology and Health
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS