Effects of Antibiotic Consumption on Children 2-8 Years of Age Developing Asthma / 한국역학회지
Epidemiology and Health
;
: e2014006-2014.
Article
in English
| WPRIM
| ID: wpr-721291
ABSTRACT
OBJECTIVES:
Antibiotic exposure in children is a possible contributor to the increasing asthma prevalence in several countries. The present study aimed to investigate the association between antibiotic exposure and the risk of developing childhood asthma at 2-8 years of age.METHODS:
A case-control study was undertaken among children aged 2-8 years old between March and September 2010 in the Urmia district in the northwest of Iran. The cases were doctor-diagnosed asthmatic children based on Global Initiative for Asthma criteria (n=207), and the controls were children without respiratory symptoms (n=400) selected by frequency matching by age and gender. Clinical data including antibiotic exposure was collected by a validated and reliable questionnaire, which was completed by interviewing parents/guardians.RESULTS:
Antibiotic consumption during the first year of life increased the odds ratio [OR] of asthma symptoms at 2-8 years of age (crude OR, 2.26; 95% confidence interval [CI], 1.53-3.35; p<0.01), and the strength of association was similar after adjusting for a family history of asthma or atopic disorder, preterm delivery, birth order, and delivery method (adjusted OR, 1.91; 95% CI, 1.27-2.88; p=0.03).CONCLUSIONS:
Our study suggests that antibiotic consumption in children was associated with an increased risk of childhood asthma, and an additional confirmative study is needed.
Full text:
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Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Case-Control Studies
/
Odds Ratio
/
Birth Order
/
Prevalence
/
Surveys and Questionnaires
/
Iran
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Epidemiology and Health
Year:
2014
Type:
Article
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