Efficacy of the Arbekacin and Teicoplanin Combination on Glycopeptide Intermediate Staphylococcus aureus in a Rabbit Model of Endocarditis
Infection and Chemotherapy
;
: 102-106, 2008.
Article
in English
| WPRIM
| ID: wpr-721650
ABSTRACT
BACKGROUND:
There have been no reports to evaluate the usefulness of combination therapy with glycopeptide and arbekacin in endocarditis by in vivo model. MATERIALS ANDMETHODS:
We investigated the efficacy of the arbekacin and teicoplanin combination on glycopeptide intermediate Staphylococcus aureus (GISA) in rabbit model of endocardits. GISA Mu50 strain was used for the experiment. The rabbit model of aortic valve endocarditis as described previously was used. Treatment was started 20h later inoculation with teicoplanin alone (at 20 mg/kg of body weight intramuscularly every 12 hours for 4 days after loading dose of 40 mg/kg of body weight intramuscularly), arbekacin alone (5 mg/kg of body weight intramuscularly every 12h for 4 days), or teicoplanin plus arbekacin. The results of therapy for experimental endocarditis due to Mu50 showed that teicoplanin and arbekacin combination was more effective than the administration of both drugs alone in reducing the log10CFU/g of aortic vegetation (P<0.05).CONCLUSION:
The combination of teicoplanin and arbekacin was more effective against GISA (Mu50) than both drugs alone in vivo endocarditis model.
Full text:
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Index:
WPRIM (Western Pacific)
Main subject:
Aortic Valve
/
Sprains and Strains
/
Staphylococcus
/
Staphylococcus aureus
/
Body Weight
/
Dibekacin
/
Teicoplanin
/
Endocarditis
Language:
English
Journal:
Infection and Chemotherapy
Year:
2008
Type:
Article
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