A Phase 2 Trial of PEF ( Cispatin , Etoposide , 5-Fluorouracil ) Chemotherapy for Metastatic Stomach Cancer / 대한암학회지
Journal of the Korean Cancer Association
;
: 900-906, 1998.
Article
in Korean
| WPRIM
| ID: wpr-72169
ABSTRACT
PURPOSE:
To determine the activity and toxicities of PEF (Cisplatin, Etoposide, 5-Fluorouracil) chemotherapy for stomach cancer. MATERIALS ANDMETHODS:
Patients with previously untreated metastatic stomach cancer were treated with PEF regimen which consisted of cisplatin (20 mg/m2 i.v. days 1~5), etoposide (100 mg/m2 i.v. days 1, 3, 5), and 5-fluorouracil (5-FU)(800 mg/m2 i.v. infusion for 12 hours days 1~5). Chemotherapy was repeated every 3 weeks until disease progressed or toxicities were intolerable.RESULTS:
Between May 1989 and July 1990, 40 patients were enrolled in this protocol. Twelve patients were lost to follow up after one cycle of chemotherapy and inevaluable. After 2~8 cycles (median 3) of chemotherapy, 20 out of 28 evaluable patients showed objective responses without any complete response, making the response rate 71% (95% confidence interval 54~89%). The responses lasted from 4+ to 39 weeks (median 38 weeks). The overall survival of total evaluable patients was 4+ ~50+ weeks (median 38 weeks). Among total 109 cycles of chemotherapy, cycles were delayed or doses were reduced in 48 cycles (44%) because of leukopenia (in 61 cycles 56%) and/or thrombocytopenia (in 14 cycles 13%). However, there was no treatment-related death. Nausea/vomiting and alopecia were experienced in most of patients. The stomatitis was experienced in 7 patients (25%) but completely reversible. In contrast, the peripheral neuropathy which developed in 4 patients (14%) after 5 cycles of chemotherapy was not reversible.CONCLUSION:
The PEF regimen was active and tolerable in stomach cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach
/
Stomach Neoplasms
/
Stomatitis
/
Thrombocytopenia
/
Cisplatin
/
Peripheral Nervous System Diseases
/
Drug Therapy
/
Alopecia
/
Etoposide
/
Lost to Follow-Up
Type of study:
Practice guideline
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Cancer Association
Year:
1998
Type:
Article
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