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Pharmacokinetics and Pharmacodynamics of Antibiotics : General Concepts and Recent Advances / 감염과화학요법
Infection and Chemotherapy ; : 140-147, 2008.
Article in Korean | WPRIM | ID: wpr-721702
ABSTRACT
Pharmacokinetics (PK) of antibiotics can be considered as the absorption, distribution, and elimination of drug. Pharmacodynamics (PD) is the relationship between concentration of drug and the antimicrobial effect. Time course of antibiotic activity is a reflection of the interrelationship between PK and PD. Over the past decades, considerable data have been derived from in vitro, in vivo models and infected patients. The time course activity characteristics of concentration effect, and postantibiotic effects, determine the typical patterns of antibiotic activity according to the PD classification. Furthermore, the pattern of antibiotic activity over time is an important determinant of optimal dosage regimens. This review will focus on general concepts and the applications of PK/PD to antibiotic therapy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Absorption / Anti-Bacterial Agents Type of study: Prognostic study Limits: Humans Language: Korean Journal: Infection and Chemotherapy Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Absorption / Anti-Bacterial Agents Type of study: Prognostic study Limits: Humans Language: Korean Journal: Infection and Chemotherapy Year: 2008 Type: Article