Failure of Cephalosporin Treatment for Bloodstream Infection Caused by Apparently Susceptible Klebsiella pneumoniae which Produced DHA-1 beta-Lactamase Induced by Clavulanic Acid / 감염과화학요법
Infection and Chemotherapy
; : 127-131, 2004.
Article
in En
| WPRIM
| ID: wpr-721801
Responsible library:
WPRO
ABSTRACT
BACKGROUND: The therapeutic option is limited for the infections caused by organisms producing plasmid- mediated AmpC beta-lactamases, increasingly identified worldwide. Two sporadic patients with bacteremia caused by K. pneumoniae possessing an unusual inducible beta-lactam resistant phenotype were found in a university hospital. RESULTS:We conducted antibiotic susceptibility test according to NCCLS guideline. Also, we characterized beta-lactamase by isoelectric focusing. RESULTS: DHA-1 gene conferred the resistant phenotype. The patients had experienced treatment failure when treated with extended-spectrum cephalosporin. For the isolates the cephalosporin resistance was induced by clavulanic acid (and cefoxitin). CONCLUSION: Theses results suggest that the extended-spectrum cephalosporins might not provide optimal therapeutic option for inducible DHA-1-producing K. pneumoniae infection, even when the pathogens are susceptible in vitro.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Phenotype
/
Pneumonia
/
Beta-Lactamases
/
Cephalosporins
/
Bacteremia
/
Treatment Failure
/
Cephalosporin Resistance
/
Clavulanic Acid
/
Isoelectric Focusing
/
Klebsiella
Type of study:
Guideline
Limits:
Humans
Language:
En
Journal:
Infection and Chemotherapy
Year:
2004
Type:
Article