Optimal Timing of Zoster Vaccination After Shingles: A Prospective Study of the Immunogenicity and Safety of Live Zoster Vaccine
Infection and Chemotherapy
;
: 311-318, 2018.
Article
in English
| WPRIM
| ID: wpr-721810
ABSTRACT
BACKGROUND:
Zoster vaccination is recommended for people with a history of herpes zoster (HZ), but the most effective timing of vaccine administration after zoster illness is unresolved. This prospective observational study compared the immunogenicity and safety of administering HZ vaccine at 6-12 months and 1-5 years after zoster illness. MATERIALS ANDMETHODS:
Blood samples were collected before the administration of live zoster vaccine and 6 weeks after vaccination. Varicella-zoster virus (VZV) IgG concentrations and T-cell responses were assessed by glycoprotein enzyme-linked immunosorbent assay and interferon-γ enzyme-linked immunospot assay (ELISPOT), respectively.RESULTS:
The baseline geometric mean value (GMV) of VZV IgG was higher in the 6-12 months group than in the 1-5 years group (245.5 IU/mL vs. 125.9 IU/mL; P = 0.021). However, the GMV increased significantly in both groups (P = 0.002 in the 6-12 months group; P 1 year after zoster illness. TRIAL REGISTRATION ClinicalTrials.gov Identifier NCT02704572
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin G
/
Enzyme-Linked Immunosorbent Assay
/
Glycoproteins
/
T-Lymphocytes
/
Prospective Studies
/
Vaccination
/
Herpesvirus 3, Human
/
Herpes Zoster Vaccine
/
Enzyme-Linked Immunospot Assay
/
Observational Study
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Infection and Chemotherapy
Year:
2018
Type:
Article
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