Metabolic Complications in Korean HIV/AIDS Patients Receiving Highly Active Anti-retroviral Therapy / 감염과화학요법
Infection and Chemotherapy
;
: 197-206, 2004.
Article
in Korean
| WPRIM
| ID: wpr-722295
ABSTRACT
BACKGROUND:
Since the introduction of HAART (Highly Active Anti-Retroviral Therapy), metabolic com- plications have been reported with varying prevalence. We performed a retrospective study to evaluate the incidence and risk factors of metabolic complications arising in Korean HIV/AIDS patients. MATERIALS ANDMETHODS:
66 HIV positive patients on combination therapy between 1998 June to 2002 June with at least 1 protease inhibitor (PI) or/and Non-nucleoside reverse transcriptase inhibitors (NNRTI) were reviewed. Hyperglycemia was defined as serum glucose >140 mg/dL on 2 or more occasions; diabetes as any random serum glucose >200 mg/dl; hypercholesterolemia as serum cholesterol >240 mg/dL; hypertriglyceridemia as serum triglyceride >200 mg/dL. We used SPSS version 9.0 for statistical analysis. One way ANOVA was used to compare the treatment groups. Multinominal logistic regression analysis was used for risk factor analysis.RESULTS:
66 patients were analyzed and total duration of follow up was 138 patient-years. The incidence of metabolic complication was 20.3%. Incidence of hypertriglyceridemia, hypercholesterolemia, hyperglycemia, and diabetes were 12.3%, 5.8%. 1.4%, 4.3% respectively. On risk factor analysis, factors contributing to the development of metabolic complication were age>35 years (P= 0.020) and baseline serum triglyceride >140 mg/dL (P=0.001). Baseline CD4 count 6 months (P=0.055) were associated with development of metabolic complications with borderline significance.CONCLUSION:
The incidence of metabolic complication among Korean HIV/AIDS patients receiving HAART is 20.3%. Older age and high baseline triglyceride were risk factors for development of metabolic complications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protease Inhibitors
/
Triglycerides
/
Blood Glucose
/
Hypertriglyceridemia
/
Logistic Models
/
Cholesterol
/
Incidence
/
Prevalence
/
Retrospective Studies
/
Risk Factors
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Infection and Chemotherapy
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS