Electrophysiologic Responses of Neuromuscular Junction by High Dose of Botulinum Toxin A Injection: Local and Distant Effects
Journal of the Korean Academy of Rehabilitation Medicine
;
: 152-160, 2002.
Article
in Korean
| WPRIM
| ID: wpr-722647
ABSTRACT
OBJECTIVE:
The purpose of this study was to measure the local and distant effects of BTX-A of different dosage through the electrophysiologic study.METHOD:
Sixteen Sprague-Dawley rats were used and divided into four groups by the dosage of BTX-A (Botox , Allergan Co.) 2, 4, 6, 8 U for each of the four rats. BTX-A was injected into tibialis anterior (TA) muscles. Slow rate (3 Hz) and fast rate (20 Hz) repetitive nerve stimulation test (RNST) was performed before and after BTX-A injection. The schedule of postinjection was as follows 2 days after the injection, every seven days till 10 weeks postinjection, once a month for 4 months.RESULTS:
In the fast rate RNST of the treated TA muscle, dose-dependent increments were seen on the 2nd day postin jection and thereafter dose-dependent decrements appeared and weakened over the course of time. In the slow rate RNST of the treated TA, dose-dependent decrements were observed through ten weeks postinjection in all groups. In the fast rate RNST of the untreated TA, incremental responses were produced in all groups in a dose-dependent manner. In the slow rate RNST of the untreated TA, there were no changes.CONCLUSION:
The BTX-A injection causes local paralysis in the treated muscles and presynaptic dysfunction of the neuro muscular junction in the distant untreated muscles in a dosedependent manner. This study could not be differentiated between neuromuscular dysfunction, myopathy or neuropathy through these RNST studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paralysis
/
Appointments and Schedules
/
Botulinum Toxins
/
Rats, Sprague-Dawley
/
Muscles
/
Muscular Diseases
/
Neuromuscular Junction
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2002
Type:
Article
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