Effects of Enriched Environment on Locomotion and Cognition in Neonatal Rats with Hypoxic-Ischemic Encephalopathy
Journal of the Korean Academy of Rehabilitation Medicine
;
: 1-9, 2010.
Article
in Korean
| WPRIM
| ID: wpr-723101
ABSTRACT
OBJECTIVE:
To investigate the effect of environmental enrichment on the cognitive and motor development in the experimental hypoxia-ischemic encephalopathy neonatal rat model.METHOD:
Hypoxic-ischemic encephalopathy models were made in neonatal Sprague-Dawley rats at 3 days of age by ligating the unilateral carotid artery followed by inhalation of 8% oxygen and raised in the enriched environment (n=10), treadmill exercise (n=8) and non-stimulation (n=10) from the 3rd to 8th weeks of age. Neurobehavioral and histopathological changes were compared.RESULTS:
The neurobehavioral tests of the rats with hypoxic-ischemic encephalopathy showed prolonged latencies of achievement for cliff avoidance and negative geotaxis (p<0.05). Persisting abnormality into adult life of limb placing improved in exercise and enriched environment groups and spatial learning and memory in a water maze recovered in the rats with enriched environment (p<0.05). The density of dendritic spine increased in the hippocampus with enriched environment (p<0.05).CONCLUSION:
The present study supports the possibilities of the positive effects after the enriched environment in the developing brain with hypoxic injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Achievement
/
Brain
/
Carotid Arteries
/
Inhalation
/
Rats, Sprague-Dawley
/
Cognition
/
Hypoxia-Ischemia, Brain
/
Dendritic Spines
/
Extremities
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2010
Type:
Article
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