Nonaka Myopathy: A case report
Journal of the Korean Academy of Rehabilitation Medicine
;
: 288-291, 2004.
Article
in Korean
| WPRIM
| ID: wpr-723191
ABSTRACT
Nonaka myopathy (NM) or distal myopathy with rimmed vacuoles was an autosomal recessive muscle disease with preferential involvement of the tibialis anterior and sparing quadriceps muscles in young adulthood. Patients with NM usually showed slightly elevated serum creatine kinase (CK) levels and characteristic rimmed vacuoles in muscle biopsy. Recently, the UDP-N-acetylglucosamine-2-epimerase/N-ace-tylmannosamine kinase (GNE) gene was identified as the identified as the causative gene for NM. Here we reported a NM patient carrying homozygous mutations (V572L) of the GNE gene. To the best of our knowledge, this was the first report of genetically confirmed NM in Korea and NM should be included in the differential diagnosis of slowly progressive weakness of distal legs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphotransferases
/
Vacuoles
/
Biopsy
/
Creatine Kinase
/
Distal Myopathies
/
Diagnosis, Differential
/
Quadriceps Muscle
/
Korea
/
Leg
/
Muscular Diseases
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2004
Type:
Article
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