Integrated Test for Screening in Down Syndrome as a Predictor of Adverse Pregnancy Outcomes
Journal of Genetic Medicine
;
: 74-80, 2009.
Article
in Korean
| WPRIM
| ID: wpr-72323
ABSTRACT
PURPOSE:
To assess the value of first-trimester pregnancy-associated plasma protein-A (PAPP-A), nuchal translucency (NT) and second-trimester alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol (uE3), and inhibin-A in predicting pregnancy complications other than fetal aneuploidy. MATERIALS ANDMETHODS:
A retrospective study in 3,121 singleton pregnancies with integrated testing was performed at Kangnam CHA hospital between January 2005 and December 2006. Baseline characteristics, pregnancy outcomes, and serum marker levels were obtained by review of the medical records. We analyzed the data to identify associations between the integrated screening markers and adverse pregnancy outcomes. Statistical analyses were performed with the SPSS program.RESULTS:
In preterm labor and preeclampsia, high AFP, hCG, and inhibin-A levels and low PAPP-A and NT levels were found to be significantly correlated (P<0.05). Elevated second-trimester inhibin- A levels were associated with preeclampsia (odds ratio 2.843), low birth weight (odds ratio 1.446), and preterm labor (odds ratio 1.287), and while decreased first-trimester PAPP-A levels were associated with preeclampsia (odds ratio 0.51) and preterm labor (odds ratio 0.75).CONCLUSION:
First- and second-trimester maternal serum markers screening can be used for predicting high-risk pregnancies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pre-Eclampsia
/
Pregnancy-Associated Plasma Protein-A
/
Pregnancy Complications
/
Prenatal Diagnosis
/
Infant, Low Birth Weight
/
Pregnancy Outcome
/
Biomarkers
/
Alpha-Fetoproteins
/
Mass Screening
/
Medical Records
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
Korean
Journal:
Journal of Genetic Medicine
Year:
2009
Type:
Article
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