The Effects of Hyperosmolar Dextrose and Autologous Serum Injection in the Experimental Articular Defect of Rabbit
Journal of the Korean Academy of Rehabilitation Medicine
;
: 173-178, 2006.
Article
in Korean
| WPRIM
| ID: wpr-723417
ABSTRACT
OBJECTIVE:
Although the clinical effects of prolotherapy on osteoarthritis has been reported, there have been few previous studies showing the effects as a proliferant on articular cartilage. Also the autologous blood has been reported to used as a growth factor stimulant recently, we were trying to use dextrose and autologous serum for tissue regeneration respectively and evaluated the proliferative effect of autologous serum comparing with that of dextrose.METHOD:
Twenty four rabbits were used for this study. The rabbits were divided into three groups. Group A did not get any special treatment. Group B was treated with 10% dextrose and group C with autologous serum. Six weeks later, gross appearance and histologic findings were evaluated.RESULTS:
After sacrifice, the gross inspection of the knee joints revealed that group B and C were filled with the translucent tissue in defective cartilage. Group A still had defective cartilage. Histologic evaluation revealed increase of cellularity in the defect of the injected specimens when compared with the control. There was no morphological difference between group B and C.CONCLUSION:
The repair process of the articular cartilage defects using dextrose and autologous serum were shown to be more effective than that of control group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Regeneration
/
Cartilage
/
Cartilage, Articular
/
Glucose
/
Knee Joint
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS