Relevance of Behavioral Test in the Photothrombotic Stroke Rat Model
Journal of the Korean Academy of Rehabilitation Medicine
;
: 135-141, 2006.
Article
in Korean
| WPRIM
| ID: wpr-723424
ABSTRACT
OBJECTIVE:
The purpose of this study was to find reliable behavioral measures for the evaluation of motor dysfunction in photothrombotic ischemia rat model.METHOD:
Male Sprague-Dawley rats were trained for behavioral test including tray reaching task (TRT), single pellet reaching task (SPRT), and rotarod task (RRT) for more than 2 weeks. Photothrombotic ischemia was induced in a stereotactically held rats using Rose Bengal dye (20 mg/kg) and cold light. Rats were assigned to either control (n=10) or experimental ischemic group (n=10). Post-lesional behavioral tests were performed for 4 weeks after confirmation of lesion by magnetic resonance imaging (MRI), followed by histological examination.RESULTS:
RRT showed no difference between control and experimental group. SPRT and TRT showed significant difference between control and experimental group (p<0.05). SPRT could well demonstrate the recovery of motor dysfunction after over time.CONCLUSION:
SPRT could be the most reliable test to measure not only motor dysfunction but also motor recovery in unilateral motor cortex lesion of photothrombotic ischemia rat model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rose Bengal
/
Thrombosis
/
Magnetic Resonance Imaging
/
Rats, Sprague-Dawley
/
Stroke
/
Models, Animal
/
Ischemia
/
Motor Cortex
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2006
Type:
Article
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