Comparison of the Findings of DDST (II), Brain SPECT and Brain MRI in Cerebral Palsy Children

ABSTRACT

OBJECTIVE: To evaluate the clinical values of the DDST II (Denver Developmental Screening Test, 2nd revision), 99mTc HMPAO brain single photon emission computed tomography (SPECT) findings and brain magnetic resonance imaging (MRI) in the assessment of cerebral palsy children. METHOD: Twenty-two children with cerebral palsy were investigated. Four profiles of DDST (II) were summated to a monthly age according to each developmental status. 99mTc HMPAO brain SPECT imagings were analyzed for the calculation of the perfusion defect indices. The clinical severities were scored as mild to severe, and were compared to a motor age of Maryland criteria. The presence of abnormal findings of brain MRI was also checked. RESULTS: (1) The gross and fine motor profiles of DDST (II) were significantly different between normal and abnormal findings of the brain SPECT in cerebral palsy children. (2) The region of interests ROIs in brain SPECT correlated with many profiles of DDST (II), 1) prefrontal area of the brain SPECT and language profile of DDST (II), 2) premotor area and gross motor/language profile, 3) thalamic area and social-personal profile, 4) basal ganglia area and gross motor/language proflie. respectively. (3) There was no relationship between each profile of DDST (II) and brain MRI findings. CONCLUSION: The DDST (II) and Brain SPECT seemes to be more useful than the brain MRI for the functional assessment of cerebral palsy children.